Our Publications

From the lab

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade.

The Journal of Clinical Investigation, 2018, 128(10):4654-4688

Hsu J.+, Hodgins J.J.+, Marathe M., Nicolai C.J., Bourgeois-Daigneault M.C., Trevino T.N., Azimi C.S., Scheer A.K., Randolph H.E., Thompson T.W., Zhang L., Iannello A., Mathur N., Jardine K.E., Kirn G.A., Bell J.C., McBurney M.W., Raulet D.H.*, Ardolino M.*

*co-corresponding authors and co-senior authors

Killers 2.0: NK Cell Therapies at the Forefront of Cancer Control.

The Journal of Clinical Investigation, 2019, 129(9):3499-3510

Hodgins J.J., Khan S.T., Park M., Auer R.C., Ardolino M.

Is Innate Immunity our best weapon for flattening the curve?

The Journal of Clinical Investigation, 2020, 130(8):3954-3956

Angka L., Market M., Ardolino M.*, Auer R.C.*


*corresponding author and co-senior author

Flattening the COVID-19 curve with Natural Killer cell based immunotherapies

Frontiers in Immunology, 2020, 11:1512

Market M., Angka L., Martel A., Bastin D., Olanubi O., Tennakoon G., Boucher D., Ng J., Ardolino M.*, Auer R.C.*

*corresponding author and co-senior author

The two faces of NK cells in oncolytic virotherapy

Cytokines and Growth Factors Reviews, 2020, 11:1512

Marotel M., Hasim M.S., Hagerman A., Ardolino M.

Immunotherapy for sarcomas: new frontiers and unveiled opportunities.

Journal of Immunotherapy of Cancer, 2021, 9(2):e001580

K. Birdi#, A. Jirovec#, S. Cortés-Kaplan#, J. Werier, C. Nessim, J.S. Diallo*, M. Ardolino*

#: equal contribution / *: equal contribution

When Killers become thieves: trogocytosed PD-1 inhibits NK cells in cancer

Science Advances, 2022, 8(15)

Hasim M.S., Marotel M., Hodgins J.J., Vulpis E., Makinson O.J., Asif S., Shih H.Y., Scheer A.K., MacMillan O., Alonso F.G., Burke K.P., Cook D.P., Li R., Petrucci M.T., Santoni A., Fallon P.G., Sharpe A.H., Sciumè G., Veillette A., Zingoni A., Gray D.A., McCurdy A., Ardolino M.

†: equal contribution

A new functional screening platform identifies colistin sulfate as an enhancer of Natural Killer cell cytotoxicity.

Cancers, 2022, 14(12), 2832

Cortés-Kaplan S., Hasim M.S., Kaczmarek S., Taha Z., Maznyi G., McComb S., Lee S.H., Diallo J.S., Ardolino M.

More than a ligand: PD-L1 promotes oncolytic virus infection via a metabolic shift that inhibits the type I interferon pathway

Submitted to BioRxiv

Hodgins J.J., Abou-Hamad J., Hagerman A., Yakubovich E., Tanese de Souza C., Marotel M., Buchler A., Fadel S., Park M., Fong-McMaster C., Crupi M., Bell J.C., Harper M-E., Rotstein B.H., Auer R.C., Vanderhyden B., Sabourin L., Bourgeois-Daigneault M.C., Cook D., Ardolino M.

Advancements in CAR-NK therapy: lessons to be learned from CAR-T therapy.

Front. In Immunol., 2023, 14

Kilgour M.K., Bastin D.J., Lee S.H.*, Ardolino M.*, McComb S.*, Visram A.*

*co-senior author

Collaborations

Loss of Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.

Oncogene, 2020, 39(23):4592-4602

Al-Zahrani K., Abou-Hamad J., Pryce B., Cook D., Hodgins J.J., Labreche C., Robineau‑Charette P., de Souza C., Bell J.C., Auer R.C., Ardolino M., Vanderhyden B., Sabourin L.

Muscle-Specific Deletion of SLK/Stk2 Enhances p38 Activity and Myogenesis in mdx Mice

BBA Molecular Cell Research, 2021, 1868(2), 118917

Pryce B.P., Labreche C., Hamoudi D., Abou-Hamad J., Al-Zahrani K.N., Hodgins J.J., Boulanger-Piette A., Bossé S., Balog-Alvarez C., Frenette J., Ardolino M., Kornegay J.N., Sabourin L.

Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver

European Journal of Immunology, 2021, 51(11):2568-2575

Di Censo C., Marotel , Mattiola I., Müller L., Scarno G., Pietropaolo G., Peruzzi G., Laffranchi M., Mazej J., Hasim M.S., Asif S., Russo E., Tomaipitinca L., Stabile H., Lee S.H., Vian L., Gadina M., Gismondi A., Shih H.-Y., Mikami Y., Bernardini G., Bonelli M., Sozzani S., Diefenbach A., Ardolino M., Santoni A., Sciumè G.

CEACAM1 is a direct SOX10 target and inhibits melanoma immune infiltration and stemness

iScience, 2022, 25(12):105524

Abou-Hamad J, Hodgins JJ, de Souza CT, Garland B, Labrèche C, Marotel M, Gibson C, Delisle S, Pascoal J, Auer RC, Ardolino M, Sabourin L

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies.

Nature Communications, 2023, 14

Azad T., Rezaei R., Singaravelu R., Pelin A., Boulton S., Petryk J., Onsu K.A., Martin N.T., Hoskin V., Ghahremani M., Marotel M., Marius R., He X., Crupi M.J.F., Hoang H-D., Nik-Akhtar A., Ahmadi M., Zamani N.K., Golshani A., Alain T., Greer P., Ardolino M., Dickinson B.C., Tai L-H., Ilkow C.S., Bell J.C.

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Address: Ottawa Hospital Research Institute – 501 Smyth Road – Cancer Center – Ottawa, ON K1H 8M2

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Mail: mardolino@ohri.ca

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